Fans who fly via Nairobi, Kenya, must produce either a International Certificate of Vaccination or Prophylaxis (ICVP) documenting vaccination against yellow fever, or a certificate of exemption, on arrival in South Africa.
The HPA advised that for some travellers a letter of medical exemption will be appropriate.
There is no risk of yellow fever in South Africa.
The HPA advised that health professionals should be aware of the certificate requirement for South Africa and be prepared to discuss the risks of vaccination and appropriate options for travellers.
Advice and information about health risks associated with travel to South Africa are available at the National Travel Health Network and Centre website.
The advice follows warnings about a recent outbreak of Rift Valley Fever in the country, which has claimed 13 lives since April.