Variable BP risks kidney damage

BP variation increases risk of kidney damage in type-1 diabetes patients, research has shown.

Kidney disease related to BP (Photograph: SPL)
Kidney disease related to BP (Photograph: SPL)

Researchers from Hull Royal Infirmary found that variation in BP is a risk factor in the development of nephropathy and its effects are independent of mean BP.

The team studied data from the Diabetes Control and Complications Trial (DCCT). The DCCT compared the effect of intensive versus conventional blood glucose control on the development of microvascular complications.

Researchers studied 1,261 patients from the DCCT and looked at the variability of BP readings between consultations. Primary outcomes were defined as instances of retinopathy and nephropathy.

They found that while mean diastolic BP was linked to development of retinopathy, BP variability was not as important. However, the researchers believe BP variability contributed to the appearance of nephropathy among patients.

They concluded: 'In contrast to retinopathy, visit-to-visit variability in BP consistently added to mean BP in predicting the risk of developing albuminuria among the patients.

'This observation could have implications for the management and treatment of BP in patients with type-1 diabetes.'

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