Bacteria that produce extended-spectrum beta-lactamases (ESBLs) are a known cause of healthcare-associated multi-drug-resistant infection, and are now spreading in the community.
The commonest ESBL-producing infections are UTIs caused by E coli. These are resistant to most antibacterial drugs used to treat UTIs.
Patients with lower UTI in areas where there is any risk of infection with a ESBL-producing organism should be treated with nitrofurantoin, which is effective against these strains.
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