US research finds genes behind gout

Three genes have been discovered that could increase the risk of developing gout by 40-fold, say US researchers.

The research confirmed the association of the gene SCLA29 with gout and also revealed two more genes ABCG2 and SLC17A3 which are likely to be kidney urate transporters.

The researchers, from the National Heart, Lung and Blood Institute in Maryland, say that the findings could be used to help guide clinical treatment decisions, especially with respect to selection of drugs that are known to increase uric acid concentration.

The Lancet Online 2008

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