The couple - potentially a husband and wife team - would need to be 'great characters, with huge chemistry'. No previous TV experience is necessary, although the couple need to be 'engaging and confident on camera'.
Both need to be clinically trained, but although the show's producers are looking for two GPs they would consider couples including one GP and a nurse or doctor from another discipline.
Applications from men who are 'great, confident characters' would also be considered, potentially to be paired with a female presenter.
The show, to appear on Channel 5, would help members of the public with their health problems.
Would-be presenters should send their name, job title, photo, contact details to the programme's producers at email@example.com, or call on 01908 933901.