|TEST YOUR KNOWLEDGE ON HAEMATOLOGY|
|What are the commonest symptoms and signs of myelofibrosis?|
|Severe, unexplained fatigue is the commonest symptom. Clinical examination reveals splenomegaly in almost all cases.|
|How do you diagnose myelofibrosis?|
|Peripheral blood film reveals anaemia and a leucoerythroblastic picture in combination with teardrop-shaped red cells. Bone marrow examination shows the increased fibrosis which is confirmatory in the clinical setting.|
|What complications can a patient with myelofibrosis develop?|
|Extra-medullary haematopoiesis can develop in any organ and cause symptoms related to the specific site. Repeated transfusions to correct anaemia can cause iron overload. Marked splenomegaly can be a risk factor for splenic infarcts. Myelofibrosis can transform to acute leukaemia.|
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