Test your knowledge on chronic leukaemia

Read the haematology article on chronic leukaemia then answer these three questions to check your understanding. You may want to document your answers and any learning points to save in your CPD Organiser along with the article.

Read our clinical feature on chronic leukaemia

Question 1

 What are the signs expected in a patient presenting with a chronic leukaemia?


Many patients have no signs initially but as the disease accumulates splenomegaly will become obvious in CML. Widespread, rubbery lymphadenopathy sometimes with splenomegaly can be found in CLL. Pallor tends to be a late presentation.

Question 2

 What is the diagnostic test for CML?

 The detection of the Philadelphia chromosome or more specifically the detection of the BCR/ABL oncogene.
Question 3
What is the prognosis in CLL?

This depends on the stage of the disease and can also be altered by certain mutational events. Patients with stage A disease should expect a median life expectancy of over 10 years, often without treatment, whereas those with stage C, the median life expectancy is down to three years.

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