Targeting pain

A single injection of bisphosphonate can eliminate the painful symptoms of Paget's disease for nearly three years.

Researchers compared 152 patients who received a 15-minute infusion of 5mg zoledronic acid with 115 patients who were given daily risedronate. After 20 months, 57 risedronate patients lost their therapeutic response, compared with only three patients given the zoledronic acid (Aclasta) who kept symptoms under control for up to three years. Pictured is a coloured X-ray showing a skull with mottled appearance due to the increased porosity characteristic in Paget's disease.

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