GPonline understands that the new parliamentary under-secretary of state for health will be given the primary care portfolio when ministerial responsibilities are announced shortly.
Mr Brine, Conservative MP for Winchester and Chandler's Ford, was previously assistant government whip and has also served as parliamentary private secretary to Jeremy Hunt.
First elected to parliament in 2010, Mr Brine served on the justice select committee where he took an interest in rehabilitation.
He will take over the primary care brief from David Mowat who lost his seat in the general election.
Before he was elected as an MP Mr Brine campaigned against the Labour government’s cuts to NHS services.
Mr Brine said of his appointment as health minister: ‘Health has always been a great interest for me, both locally and in terms of national policy. I am really looking forward to working as part of the team at Richmond House to ensure we build a health and social care system that is among the safest and highest-quality anywhere in the world.
‘We've big ambitions around mental health provision and securing greater access to GPs which we can only deliver if we keep a strong economy that provides the resources our NHS needs. This new role is a tremendous opportunity to work in an area I am passionate about and to ensure the voice of Winchester & Chandler's Ford is heard at the heart of government.’
Mr Brine's fellow new appointee to the ranks of health ministers, Jackie Doyle-Price, recently sparked anger among GPs over her claims that GPs have enough money to cope with patient demand.