Preventive treatment for sepsis has yet to be identified, but the latest study findings suggest that statins may be able to minimise the risk of sepsis in CKD patients by regulating the immune response to infection.
Statins may also play a role in reducing the production of cytokines or mitigating the vasodilatory response to cytokines that results in septic shock, say the researchers.
For this latest study, the association of statin use with the occurrence of sepsis was examined in 1,041 CKD patients who were receiving dialysis for end stage renal disease, 143 of which were statin users, enrolled at 80 US dialysis clinics over a period of three years.
Statin use was determined by review of the dialysis clinic notes and hospital discharge summaries, while a history of sepsis was collected from self-report questionnaires and hospital records from the US renal data system.
Over the duration of the study, 303 participants were hospitalised for sepsis.
The risk of hospitalisation for sepsis was 62 per cent lower among statin users than among those not using statins.