The meta-analysis of 27 statin studies, involving 39,704 people, supports previous suggestions that statins could benefit renal function.
A re-analysis of data from 21 studies that included estimated glomerular filtration rates (eGFR) showed that the change in eGFR was a statistically significant 1.22ml/min per year slower in people receiving statins than those in control groups.
Further analysis revealed that statin therapy benefited patients with CVD, who had an average change in eGFR 0.93ml/min per year slower than controls.
Statins did not significantly impact the eGFR of patients with diabetes, hypertensive kidney disease or glomerulonephritis.
Additionally, a random-effects model of 20 studies that measured proteinuria or albuminuria showed that reduction of these parameters was greater in people taking statins than those in control groups, by 0.58 units of standard deviation.
J Am Soc Nephrol Online