Both drugs have independ-ently been linked to an increased bleeding risk.
However, the latest study showed that in patients taking oral vitamin K antagonists, the use of SSRIs increased the risk of non-GI bleeding by 70 per cent - equivalent to the risk seen with an NSAID.
The study included 70,201 patients in the Netherlands who were taking oral vitamin K antagonists between 1994 and 2004.
Overall, 1,848 cases of major bleeding were recorded in this group, with 67 per cent of cases being non-GI bleeds.
SSRI use was associated with a 70 per cent increased risk of non-GI bleeding, compared with patients taking vitamin K antagonists alone.
But the combination of medications had no statistically significant effect on the risk of GI-bleeding.
The researchers conclude that patients taking an oral anticoagulant should consider taking an alternative antidepressant to SSRIs.
Comment below and tell us what you think