Single jab could provide lifelong HIV protection

Lifelong HIV protection could in future be provided by a single injection, US researchers believe.

Ahead of World Aids Day on 1 December, the team from California Institute of Technology published findings of a study of a technique known as vectored immuno-prophylaxis (VIP). This involves using a vector to encode the antibody genes that direct the expression of HIV-neutralising antibodies.

The Californian team showed that mice receiving a single infection seemed to be protected from HIV infection, even when challenged with a high dose of HIV. They believe use of this approach in humans ‘may produce effective prophylaxis against HIV’.

Writing online in Nature, the researchers said: ‘Given the level of protection that VIP has demonstrated in vivo, we believe that highly effective prophylaxis through expression of existing monoclonal antibodies against HIV in humans is achievable.’

Commenting on the findings, Professor Robin Shattock, professor of mucosal infection and immunity at Imperial College in London, said the findings were promising, but ‘much work will be needed to ensure safety, acceptability and efficacy of such an approach for human use’.

‘Nevertheless this study reinforces the potential of neutralising antibodies to prevent HIV infection and complements the drive to develop vaccine approaches designed to induce protective antibodies in at risk individuals,’ he said.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

UK COVID-19 vaccination programme tracker

UK COVID-19 vaccination programme tracker

GPs across the UK are playing a leading role in the largest-ever NHS vaccination...

London GP personally calling at-risk patients to boost COVID-19 vaccine uptake

London GP personally calling at-risk patients to boost COVID-19 vaccine uptake

London GP Dr Farzana Hussain is personally telephoning scores of patients who have...

Half of patients with possible cancer symptoms avoided contacting GP in first wave

Half of patients with possible cancer symptoms avoided contacting GP in first wave

Almost half of people who experienced potential cancer symptoms in the first wave...

GP premises need major investment to let PCNs recruit, warns BMA

GP premises need major investment to let PCNs recruit, warns BMA

Primary care networks (PCNs) are struggling to make use of hundreds of millions of...

NHS unveils £4.2m fund to tackle vaccine inequality

NHS unveils £4.2m fund to tackle vaccine inequality

CCGs with low uptake of COVID-19 vaccine in ethnic minority, marginalised or deprived...

150,000 more people with learning disabilities prioritised for COVID-19 vaccine

150,000 more people with learning disabilities prioritised for COVID-19 vaccine

Around 150,000 more people will be prioritised for COVID-19 vaccination after the...