Responses to swine flu vaccine differed in children

The two swine flu vaccines used in the UK differed in the immune response and reactions they produced in children, research suggests.

Vaccine response was different (Photograph: SPL)
Vaccine response was different (Photograph: SPL)

GlaxoSmithKline's Pandemrix vaccine, which was a split virus vaccine incorporating an adjuvant, produced a greater immune response than Baxter's Celvapan vaccine.

Pandemrix also had high sero-conversion rates in children aged less than three years, but led to more reactions in children, Dr Claire Waddington and colleagues from Oxford University's Department of Paediatrics found.

Writing in the BMJ, the researchers commented: 'These data provide important information to guide immunisation policy in an influenza pandemic and indicate the potential for improved immunogenicity of seasonal influenza vaccines in children.'

A spokeswoman for Pandemrix manufacturer GSK said initial reports on the epidemiology of the swine flu pandemic had shown that the virus had a greater impact on children as compared with the impact of seasonal influenza.

'Therefore,' she said, 'even though (the vaccine is) more reactogenic, providing a vaccine that stimulated a greater immune response may have an added benefit for this population.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

Starting your career as a newly-qualified GP

Starting your career as a newly-qualified GP

Dr Patrice Baptiste describes how she developed a portfolio career as a newly-qualified...

Limited COVID-19 vaccine supply hampers GP efforts to ramp up rollout

Limited COVID-19 vaccine supply hampers GP efforts to ramp up rollout

Limited supplies of COVID-19 vaccine have forced GP-led vaccination sites to operate...

Increase cancer tests in primary care during pandemic, suggests NHS England

Increase cancer tests in primary care during pandemic, suggests NHS England

Local health systems should look to provide more cancer diagnostics in primary care...

Daily COVID-19 vaccinations drop below level required to hit February target

Daily COVID-19 vaccinations drop below level required to hit February target

Numbers of COVID-19 vaccinations administered per day have dipped below the number...

UK COVID-19 vaccination programme tracker

UK COVID-19 vaccination programme tracker

GPs across the UK are playing a leading role in the largest-ever NHS vaccination...

GPs raise alarm over low uptake of COVID-19 vaccine in BAME patients

GPs raise alarm over low uptake of COVID-19 vaccine in BAME patients

GPs across England have raised concerns over low uptake of COVID-19 vaccination among...