The drug at the centre of the Northwick Park clinical trial investigation in London may have prompted migration of T cells to internal organs, suggest UK researchers. Six men were rushed to intensive care after being given the drug TGN1412 in March 2006. Studies in mice found that injected CD28 cells were migrating from the blood and into the organs, including the kidney and heart. TGN1412 may have activated CD28 on memory T cells. Findings were presented at the Club de la Transplantation conference, near Paris, last month.
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