Progesterone block prevents breast cancer

Blocking progesterone may prevent or halt the development of breast and ovarian cancers in women with mutations of the BRCA1 gene, findings of a study suggest.

The study of mice lacking BRCA1 and the gene p53 showed that mammary tumours developed in an average of eight months. However, mice given the progesterone antagonist mifepristone were free of tumours at 12 months.  

In mice lacking BRCA1 and p53, there were more epithelial cells with progesterone receptors than in mice lacking the gene p53 only.  

The role of progesterone in BRCA1-mutation cancers could explain why they occur only in breast and ovarian tissue.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins


Already registered?

Sign in

Just published

GP on phone in recorded consultation assessment

Consultation skills to help GP trainees pass the RCA

Dr Afsar Rizvi highlights the key skills GP trainees need to master in order to pass...

Wes Streeting

Labour promises same GP 'each appointment' and face-to-face access if patients want it

A Labour government would offer patients the chance to see 'the same doctor each...

Man wearing mask on train

UK faces serious threat from flu and COVID-19 'twindemic' this winter

There are strong indications the UK faces a dangerous 'twindemic' of COVID-19 and...

NHS sign outside a building

PCN contract overhaul defers two-week appointment target until April 2023

NHS England has announced changes to the network contract DES, including deferring...


NHS sets out priorities for extra GP funding this winter

Integrated care boards could target extra funding for general practice at phone systems,...

Shadow chancellor Rachel Reeves

Labour promises to double medical school places with tax cut reversal

A Labour government would double medical school places with funding raised from reversing...