Progesterone block prevents breast cancer

Blocking progesterone may prevent or halt the development of breast and ovarian cancers in women with mutations of the BRCA1 gene, findings of a study suggest.

The study of mice lacking BRCA1 and the gene p53 showed that mammary tumours developed in an average of eight months. However, mice given the progesterone antagonist mifepristone were free of tumours at 12 months.  

In mice lacking BRCA1 and p53, there were more epithelial cells with progesterone receptors than in mice lacking the gene p53 only.  

The role of progesterone in BRCA1-mutation cancers could explain why they occur only in breast and ovarian tissue.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins


Already registered?

Sign in

Just published

X-ray sign

Spike in TB cases prompts public health warning

Cases of TB in England have risen by 7% compared with last year, prompting a warning...

COVID-19 vaccine

GPs demand investigation as winter vaccine 'mismanagement' risks patient safety

GP leaders in England have demanded an investigation into 'mismanagement' of this...

Medical centre sign

GP 'engineering' fears as small practice contracts offered on branch-only basis

GP leaders have raised concerns over the 'engineering' of general practice after...

Close up of BMA official picket armband

SAS doctors in England to hold indicative ballot on strike action

Specialist, associate specialist and specialty (SAS) doctors in England could join...

BMA sign

BMA to oppose expansion of physician associate roles amid safety concerns

Doctors' leaders will oppose government plans to expand use of physician associates...

Doctor strikes

Public strongly back talks and new pay offer to end doctor strikes

The general public believe the government should reopen talks to end doctor strikes...