Ching-Chi Chi from Chanh Gung University College of Medicine in Chiayi, Taiwan, and colleagues from seven European countries looked at studies on the use of topical corticosteroids in pregnancy.
The researchers said evidence suggested there was not an association between the use of topical corticosteroids during pregnancy and oral cleft, pre-term delivery and fetal death.
But they concluded that, because of the risk of fetal growth restriction associated with the use of potent corticosteroids, the use mild to moderate agents should be preferred in this group.
The researchers said: ‘The available evidence does suggest that use of potent/very potent topical corticosteroids during pregnancy may be associated with placental insufficiency and low birth weight.’
The researchers considered evidence from a range of studies, including a trial involving information on 83,133 UK women from the General Practice Research Database.