Patients with Atherombosis at high risk of death or CVD event 1


Registry results published in the Journal of the American Medical Association

March 21, 2007 - Today the largest, most geographically extensive global registry of patients has revealed that those with stable atherothrombosis have a surprisingly high risk of death or major cardiovascular illness1. One in seven patients will die, have a stroke, heart attack or be hospitalised for a complication arising from atherothrombosis within one year1

The REACH Registry (REduction of Atherothrombosis for Continued Health) is a worldwide health survey of 68,236 patients in 44 countries1. It will follow patients for four years to find out how they are affected by atherothrombosis and to establish the burden of the disease in society1.  Results are now published in JAMA of the 64,977 patients who completed one year follow up.

"Atherothrombosis is a disease affecting the whole arterial system and we should be aware that having an atherothrombotic event in one vascular bed not only increases the risk of a recurrent event but also the risk of another event elsewhere. We need to be effectively managing those patients who have had an event to prevent another occurring," commented Dr Jonathan Morrell, The Conquest Hospital, Hastings.

Atherothrombosis occurs when a blood clot (thrombus) forms on fatty deposits (atheroma) in the wall of a blood vessel. This can lead to the further narrowing or blockage of the blood vessel which can then lead to serious and potentially fatal consequences:

·       Heart attack and unstable angina (collectively referred to as acute coronary syndrome), due to narrowing or blockage of coronary arteries

·       Stroke due to narrowing or blockage of cerebral arteries

·       Peripheral arterial disease, due to narrowing or blockage of the arterial vessels supplying blood to the extremities, mainly the legs

The REACH Registry is sponsored by sanofi-aventis and Bristol-Myers Squibb.


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