'No evidence' new COVID variant to blame as officials investigate potential PCR false negatives

Public health officials are investigating reports of people with classic COVID-19 symptoms testing positive on lateral flow devices (LFD) but negative on PCR amid concerns over inaccurate results.

COVID-19 testing (Photo: Getty Images)
COVID-19 testing (Photo: Getty Images)

The UK Health Security Agency's chief medical advisor said it was aware of 'some areas' reporting discrepancies between lateral flow and PCR results and was looking into the issue.

The agency said there was no evidence that a new variant of COVID-19 was responsible - and that there was also no evidence of 'technical issues' with PCR testing kits.

PHE said its general advice is that people should avoid mixing with others if they feel unwell - and advice on the NHS website says: 'If you still feel unwell after a negative test, stay at home until you're feeling better.'

PCR COVID-19 test

However, some GPs called for guidance to be updated amid concerns that potential false negative PCR results could lead people infected with COVID-19 to believe they did not need to isolate.

UK Health Security Agency chief medical adviser Susan Hopkins said: 'We have been made aware of some areas reporting positive LFD test results with subsequent negative PCR tests and we are looking into the cause.

'If you get a positive LFD test, it’s important to make sure that you then get a follow up PCR test to confirm you have COVID-19. If you have symptoms of COVID-19, self-isolate and take a PCR test. With any test it is important to carefully read and follow the instructions for use on the test kit so as to avoid any incorrect readings.'

Although lateral flow devices are understood to be less sensitive - and therefore less likely to pick up COVID-19 cases than PCR tests - false positives are extremely unlikely. The DHSC reported earlier this year that 'for every 1,000 lateral flow tests carried out, there is less than one false positive result' - explaining why the reports of negative PCRs after positive lateral flows have caused concern.

Classic symptoms

Bristol GP Dr Shaba Nabi wrote on Twitter that her son had classic COVID-19 symptoms and had 'lit up' lateral flow tests 'like the Blackpool lights' but returned a negative PCR result - and that 'lots of school kids' in her area had the same experience. 'What on earth is going on,' she asked.

A hospital consultant in the same area said here had been 'many reports' of this issue in the area, and that some people had been advised to 'carry on as if they didn't have COVID-19' after negative PCR tests.

Reports have suggested the issue has been more common in south-west England, but GPs in Manchester and Oxfordshire also reported seeing similar discrepancies between lateral flow and PCR results.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:


Just published

NHS logo on tiled wall

GP assistants are no solution to the workforce crisis in general practice, warns RCGP

Plans to recruit more than 1,000 GP assistants in practices across England 'must...

Person looking at a smartphone

GP at Hand to pull out of Birmingham next month

Babylon GP at Hand has decided to pull out of Birmingham at the end of next month,...

Dr Ollie Hart and Dr Devina Maru

How shared decision making can help GPs better meet patients' needs

Dr Ollie Hart and Dr Devina Maru are at opposite phases of their career – Dr Hart...

Stethoscope hung up in medical centre

London faces growing GP workforce gap as workload continues to soar

A surge in vacant GP posts over the past year has left half of London's practices...

Health and social care secretary Therese Coffey

Coffey targets rapid GP access over face-to-face appointments

Therese Coffey has said she 'will not be prescriptive' on how GPs see patients -...

Newspapers

Study reveals 'significant rise in anti-GP rhetoric'

Media coverage of general practice last year saw a 'significant rise in anti-GP rhetoric'...