NICE announces decision on type-2 diabetes treatment

Sitagliptin and vildagliptin have been recommended as alternatives to a sulfonylurea in NICE type-2 diabetes guidelines.

The DPP-4 inhibitors should be considered in patients taking metformin who are unsuitable for treatment with a sulfonylurea, NICE has recommended.

The guidelines also suggest that exenatide should be restricted to use for severely obese patients. The GLP-1 mimetic should only be used for patients with BMIs over 35 who have problems associated with this weight and need to improve their diabetes control, NICE says.

The guidelines also recommend use of pioglitazone or rosiglitazone as second- or third-line treatments and consider the place of long-acting insulin analogues in diabetes treatment.

Dr Amanda Adler, consultant physician at Addenbrooke's Hospital, Cambridge, and guideline development group chairman, said: ‘These guidelines acknowledge that the treatment of type-2 diabetes may require many drugs, often used simultaneously.

‘These guidelines weigh up the effectiveness of these newer agents against older, standard therapies, but also consider side-effects, patient well-being, and whether these newer drugs reflect the best use of NHS resources.'

tom.moberly@haymarket.com

  • What do you think of the new guidelines?

For more information on Guideline summaries, or to view more MIMS drug information please click here.

Comment below and tell us what you think

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

Deadline missed for PHE report on how ethnicity affects COVID-19 outcomes

Deadline missed for PHE report on how ethnicity affects COVID-19 outcomes

Public Health England (PHE) has missed its 31 May deadline for reporting on how factors...

Lockdown complacency threatens second COVID-19 spike that could 'overwhelm' NHS

Lockdown complacency threatens second COVID-19 spike that could 'overwhelm' NHS

Complacency around easing coronavirus lockdown measures could trigger a second wave...

Practices asked to 'proactively address' unmet health needs during pandemic

Practices asked to 'proactively address' unmet health needs during pandemic

GP practices in England have been told to assess where care has been delayed during...

Hertfordshire GP trainee Dr Abdorreza Sedghi dies from COVID-19

Hertfordshire GP trainee Dr Abdorreza Sedghi dies from COVID-19

A GP trainee working in Hertfordshire who has been praised for his ‘charisma and...

GP anger as shielding advice changed 'without warning'

GP anger as shielding advice changed 'without warning'

GPs have hit out at a lack of warning over changes to advice for patients on shielding...

Coronavirus: Key guidance GPs need to know about COVID-19

Coronavirus: Key guidance GPs need to know about COVID-19

GPonline provides an overview of the key guidance relating to coronavirus, including...