This year's agenda reveals that local representatives are still angry that practices facing losses of tens of thousands of pounds were left to negotiate support themselves.
The prevalence formula changed in April, leaving hundreds of practices facing five- or six-figure funding shortfalls.
A motion from Cambridge LMC 'regrets moving toward a true prevalence formula because of unintended consequences', and regrets LMCs being asked to find a local solution to a national problem.
Despite concerns about the GPC's negotiating skills, the conference will deliver a strong message to the government with an unprecedented motion of 'no confidence' in Gordon Brown.
The conference will also discuss reorganising general practices into federations to secure the future of the profession.
GPs from Cambridgeshire LMC will call for the GPC to publish a set of minimum standards for out-of-hours care as the prospect of GPs taking back out-of-hours responsibility looms.
Other ideas to be discussed include an enhanced service for detecting HIV in general practice and a working group to help GPs on APMS contracts.
Dr Nigel Watson, chief executive of Wessex LMC, said he thought the conference would be more interesting than previous years.
'Whereas in some years we are mainly restating policy, or the profession is united, this year the profession has a chance to be a bit more radical in driving change.
'There are a lot of challenges, and probably more threats. It's an exciting time for general practice and there are quite a lot of diverse opinions on its future.'
The conference will take place on 11 and 12 June at the Institute of Education in central London. GP's website www.healthcarerepublic.com will cover the conference on both days.
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