Patients with reduced estimated glomerular filtration rate (eGFR) had a 43% greater risk of stroke than those with normal rates, a Taiwanese meta-analysis showed.
The authors believe the findings may warrant the use of low eGFR as a marker for increased stroke risk.
A team led by Meng Lee of the Chang Gung University College of Medicine, Taiwan, examined 21 studies of 284,672 patients. In total, 7,863 strokes occurred in this group.
Their study compared recorded eGFR against the numbers of strokes, with a follow-up time between 3.2 to 15 years. A low rate was deemed to be below 60ml/min/1.73m2.
Patients with low eGFR at baseline were much more likely to have had a stroke. But there was no clear evidence of increased risk among patients with eGFR between 60-90ml/min/1.73m2.
The findings also suggested that Asian people with low eGFR may be at even higher risk of future stroke.