Journals Club - Colorectal cancer screening

Dr Louise Newson brings us up to date with the latest research and guidance on colorectal cancer screening.

Rectal adenicarcinoma (Photograph: SPL)
Rectal adenicarcinoma (Photograph: SPL)

Curriculum statement 5 - Healthy People: promoting health and preventing disease.

Key trials

  • The incidence of colorectal cancer (CRC) has increased in recent decades. Screening for CRC is important because it is a disease with high prevalence, has recognised precursors and early treatment is beneficial (Best Pract Res Clin Gastroenterol 2010; 24: 417-25).
  • One study showed that screening could save up to 2,400 lives every year in the UK by 2025. This means home testing kits could reduce deaths by about 16 per cent (J Med Screen 2008; 15: 163-74).
  • Testing for faecal occult blood and measurement of serum tumour markers, such as carcinoembryonic antigen, are not useful in the investigation of suspected colorectal cancer (BMJ 2007; 335: 715-8).
  • There have been technical advances in stool DNA testing so this may be used for screening in the future (J Clin Gastroenterol 2010 Sep 17. Epub ahead of print).
  • However, the new technologies of stool DNA testing (CT colonography and capsule endoscopy) are not yet cost-effective compared with the established screening (Best Pract Res Clin Gastroenterol 2010; 24: 439-49).

Evidence base

  • National guidelines for patients with IBD recommend that colonoscopic surveillance should begin after eight to 10 years for pancolitis and 15 to 20 years for left-sided disease. (Gut 2002; 51(Suppl V): v10-v12).
  • However, a Cochrane review did not find conclusive evidence that surveillance colonoscopy prolongs survival in patients with colitis (Cochrane Database Syst Rev 2006; (2): CD000279).
  • Following a colonoscopy after screening, about five in 10 people who have a colonoscopy will have a normal result, about four in 10 will be found to have a polyp, which if removed may prevent cancer developing, and about one in 10 people will be found to have cancer (NHS bowel cancer screening programme


Useful websites

Visit the Curriculum Centre for hundreds of  articles linked to key topics in the RCGP curriculum

Key Points
  • Colorectal cancer is common.
  • If bowel cancer is detected at the earliest stage there is more than a 90 per cent chance of survival.
  • Patients with IBD have an increased risk of bowel cancer.
  • Newer tests, for example stool DNA testing, may be introduced in the future.
  • Colorectal cancer screening is effective in the UK.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins


Already registered?

Sign in

Follow Us:

Just published

NHS sign

Plans to recruit 1,000 new link workers to support GP practices this winter

NHS England has set out plans to recruit an additional 1,000 social prescribing link...

BMA House

BMA prepares to ballot junior doctors on industrial action

Junior doctors will be balloted over industrial action if the government does not...

Typing on a laptop

NHS 111 systems could be offline until next week following cyber attack

NHS 111 systems could be offline until next week following the cyber attack on a...

The NHS App in the Apple App store on a smart phone

NHS England piloting online patient registration for GP practices

A new system that will allow patients to register with a GP surgery online is being...

satisfaction scale

Which parts of England have the highest and lowest GP patient satisfaction?

Patient satisfaction with GP services varies widely between PCN and ICS areas across...

Talking General Practice logo

Podcast: Improving menopause care

During August we’re bringing you some of the best interviews from series one of the...