High vitamin D dose is 'better'

Larger doses of vitamin D lead to greater reductions in bone fracture risk, an analysis of trials involving over 80,000 patients has revealed.

Researchers from the University of Zurich examined 20 trials studying fracture rates in patients over 65 years old. The trials, which included a total of 83,165 patients, looked at the effect of giving patients vitamin D rather than calcium or placebo.

The meta-analysis showed that vitamin D intake reduced patients' risk of non-vertebral fracture in a dose-dependent manner. Higher doses (482-770 IU per day) reduce fractures by at least a fifth in the over-65s, the researchers discovered.

The finding suggests that the use of higher received or achieved doses of vitamin D should be explored in future studies in order to maximise reductions in fracture risk.

tom.moberly@haymarket.com

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