High fibre intake may lower inflammation risk

Increased fibre intake is associated with a lower risk of inflammation in both the CKD and non-CKD populations, new findings suggest. National Kidney Foundation Spring Meetings 2009

Originally published on Renal and Urology News - World Review For Urologists and Nephrologists.

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Jennifer Zitterkoph, RD, and colleagues at the University of Utah in Salt Lake City, analysed data obtained from 1,103 CKD and 14,874 non-CKD participants in the Third National Health and Nutrition Examination Survey. The investigators defined CKD as a glomerular filtration rate below 60 mL/min/1.73 m2 as determined using the Modified Diet in Renal Disease study formula and defined inflammation as a C-reactive protein (CRP) level greater than 3 mg/L. Trained personnel conducted 24-hour dietary recall interviews, after which researchers estimated the dietary fibre intake and divided the amounts into tertiles: less than 10.5, 10.5-17.3, and more than 17.3 g/day.

Among CKD subjects, 51%, 46%, and 37% of those in the lowest, middle, and highest tertiles, respectively, had inflammation. Among non-CKD subjects, the proportions were 29%, 25%, and 20%, respectively, the researchers reported.

Compared with CKD subjects in the highest tertile, those in the lowest tertile had a twofold greater risk of inflammation. In the non-CKD group, those in the lowest tertile had a 38% increased risk compared with subjects in the highest tertile.

‘Interventional trials are needed to determine whether high dietary fibre intake results in decreased cardiovascular events and mortality in the CKD population,' the authors wrote.

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