In a study of 320 dyspeptic patients, those with an H pylori infection were found to be less likely to suffer erosive oesophagitis and GORD symptoms than those without.
Patients with H pylori-induced gastric atrophy seemed to be protected from both conditions, and this effect was found to be mediated through a particular pro-inflammatory genotype.
People homozygous for the proinflammatory IL-1B gene experienced greater corpus atrophy in response to H pylori infection than those with other genetic constitutions.
People with this genotype have previously been shown to have very weakly acidic gastric juice, with a pH ranging from 4.2 to 7.3, and a median of 6.5.
Gastroenterology 2006; 55: 158-64