H pylori infection may protect against GORD

Helicobacter pylori infection may protect some patients against GORD by reducing acid secretion in the stomach, Japanese researchers claim.

In a study of 320 dyspeptic patients, those with an H pylori infection were found to be less likely to suffer erosive oesophagitis and GORD symptoms than those without.

Patients with H pylori-induced gastric atrophy seemed to be protected from both conditions, and this effect was found to be mediated through a particular pro-inflammatory genotype.

People homozygous for the proinflammatory IL-1B gene experienced greater corpus atrophy in response to H pylori infection than those with other genetic constitutions.

People with this genotype have previously been shown to have very weakly acidic gastric juice, with a pH ranging from 4.2 to 7.3, and a median of 6.5.

Gastroenterology 2006; 55: 158-64

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