The guide, available on the MS Society's website, brings together interpretation of the latest NICE guidelines with the best published evidence reviewed by specialists.
It also has tools to help GPs best manage their MS patients from diagnosis to palliative care.
In 2003 NICE backed primary care use of oral steroids for the treatment for MS and now many patients are treated entirely in primary care.
However, although the guide emphasises it is important for GPs to keep good records of relapses and liaise with MS nurses and neurologists.
There is a section on emerging therapies and treatments and a set of questionnaires that GPs can use to assess the needs of their patients and track their progress.
The guide also includes details of welfare benefits available and advice on dealing with carers.