The annual awards recognise achievement and allow NICE to interact with 'key professionals' in the health service.
It will offer 10 fellowships to a range of practitiones including GPs, trust chief executives and commissioners.
Professor Peter Littlejohns, clinical and public health director at NICE, said: 'As the NHS and social care sectors face significant structural changes, it is important that both continue to provide high quality and cost effective care.
'We are looking to award a number of fellowships to senior leaders and decision makers, who will use their influence and experience to improve how care is delivered and maintain an ongoing dialogue between NICE, their employing organisations and their professions.'
NICE will also offer 10 scholarships to health professionals including registrars and nurses to support research projects.
NICE fellow Dr Monica Lakhanpaul, a consultant paediatrician, said: 'This is a fantastic opportunity for health professionals. It’s not only the access to NICE that has been advantageous but also the fact that the Fellows and Scholars Programme is a group of motivated and dynamic people who you can exchange ideas with.
'Another advantage is that you get a mentor – sometimes within the NHS we are so busy working that we forget that we also need somebody to turn to for advice.'
GPs can nominate themselves for the positions by Friday 25 November. The awards will be made in April next year.