NHS CFS said the guidance aimed to raise awareness of patient registration form fraud and to ensure action was taken to cut cases of fraud.
Guidance to GP practices on GP patient registration fraud outlines warning signs that a patient may not be genuine and will be sent to practices. It also lists documents that can be used as identification, as well as those that are readily obtained and should be treated with caution.
The NHS CFS said the guidance was produced following cases involving patients fraudulently obtaining prescription drugs. One patient used more than 40 identities to obtain drugs from Dorset GPs.
The advice follows counter-fraud action by the Scottish government earlier this year.
GPs warned patients may be put off registering after people registering at practices in Scotland were required to sign a 'counter-fraud declaration' that permits their details to be shared with agencies including the UK Border Agency.