Up to seven local teams could win grants worth a maximum of £500,000 each under the programme, run by London-based charity the Health Foundation.
The Scaling Up Improvement programme is looking for applicants from health provider organisations in the UK, where NHS services are delivered free at the point of access.
The charity aims to use the project to build an evidence base of projects that have worked locally and been developed to operate on a larger scale.
Health Foundation assistant director Dr Jane Jones said: ‘This is a really good opportunity for those working within healthcare to apply for substantial funding.
‘We are looking for projects that aim to improve healthcare delivery or the way people manage their own healthcare.’
The first phase of the application process closes at midday on Monday 16 June.