The GMC is raising the fee to cut the deficit forecast for its 2008 budget to £5.6 million.
GMC president Professor Sir Graeme Catto said the sharp rise was because of expenses that have accumulated over the years the fee remained the same.
'The time has come to raise the annual fee. We have been running a deficit budget. Next time it may be sensible to look ahead and anticipate costs that may arise,' Sir Graeme said.
GPC deputy chairman Dr Richard Vautrey said he was concerned that the profession was bearing the cost of the revalidation and relicensing process, which is due to be introduced across the NHS next year.
'To deliver what is required for revalidation and relicensing will come at a cost', he said.
'What is surprising is they have chosen now before real details of the process have come out.'
The fee for a provisional registration will be £135, full registration rises to £390 and the threshold for low income discount will rise to £21,391.
New GMC fee: £390
Annual registration fee from April 2008.