Gene tie to repeat candidiasis risk

Genes linked to recurring candidiasis have been identified by French researchers.

The team from Necker Medical School in Paris sequenced genes from patients with histories of recurring infections of Candida albicans.

The researchers found that a recessive mutation of the cytokine receptor interleukin-17A and a dominant mutation of a related receptor, interleukin-17F, underlie these chronic infections.

They concluded: 'Our report indicates that human IL-17A and IL-17F are essential for protective immunity to C albicans and, to a lesser extent, Staph aureus in the nails, skin, oral and genital mucosae, but are otherwise mostly redundant.'

The research team added that patients on treatment that blocks IL-17 should be carefully monitored by health professionals for mucocutaneous infections.

GP Online recommends

Science Online 2011

Read more

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

New standards for nurses working in advanced roles in primary care

New standards for nurses working in advanced roles in primary care

A new framework, which is backed by NHS England, has set standards for the academic...

One in six GP practices have closed or merged under NHS England

One in six GP practices have closed or merged under NHS England

One in six GP practices covering 5.4m patients have closed or merged since NHS England...

Medeconomics Live launches to help practices thrive under the new GP contract

Medeconomics Live launches to help practices thrive under the new GP contract

The new Medeconomics Live conference aims to help practices boost income, ease workload...

Staff and patients attacked in 'serious incident' at GP practice

Staff and patients attacked in 'serious incident' at GP practice

Four members of staff and four patients have been injured in a 'serious incident'...

NHS bosses to rethink 'what can realistically be delivered by PCNs'

NHS bosses to rethink 'what can realistically be delivered by PCNs'

NHS England has promised to consider 'what can realistically be delivered' by primary...

PCNs: How could the network DES draft service specifications change?

PCNs: How could the network DES draft service specifications change?

Dr Simon Hodes explains how he thinks NHS England could change the network contract...