Evidence base: Ulcerative colitis

Find all the latest information about guidelines, online resources and key texts on the management of ulcerative colitis

CT scan showing toxic megacolon requiring surgery (Author image)
CT scan showing toxic megacolon requiring surgery (Author image)

Clinical trials

The ACT 1 and ACT 2 (Acute UC Treatment) trials evaluated the use of infliximab in UC. They showed a clinically significant response in patients treated with infliximab compared with those on placebo.

Just over half the patients treated with infliximab required colectomy at a median of 140 days after the first infusion. Of those avoiding colectomy, only 17 per cent sustained a steroid-free remission.


Key text

  • Nicholls RJ, Tekkis PP. Ulcerative Colitis. In: Philips RKS. Colorectal surgery: A companion to specialist surgical practice (fourth edition). Elsevier Health Sciences.



Contributed by Dr Kenneth Fung, F2 doctor, London deanery, and Mr Joseph Dawson, specialist registrar in general surgery, North East Thames deanery


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