Enzyme may predict coronary artery calcification

Elevated levels of serum alkaline phosphatase in hemodialysis (HD) patients may predict coronary artery calcification (CAC), which is associated with cardiovascular and mortality in this population.

Originally published on Renal and Urology News - World Review For Urologists and Nephrologists.

Click here to register to receive Renal and Urology News conference highlights by email

In a study of 137 HD patients, Ronney Shantouf, MD, of the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center in Torrance, Californioa, and colleagues found that a calcium artery calcification score (CACS) of 400 or more is five times more likely to occur among patients in the highest tertile of serum alkaline phosphatase (120 mg/dL or higher) compared with those in the second tertile (reference; 85-119 mg/dL), after adjusting for age, gender, presence of diabetes mellitus, Charlson comorbidity score, dialysis vintage, interleukin-6, and serum glutamic oxaloacetic transaminase. The researchers observed no association between the first quartile of serum alkaline phosphatase and the likelihood of a CACS of 400 or more.

The mean CACS for patients with a serum alkaline phosphatase level of 120 mg/dL or higher was about twice that of subjects with lower levels.

More news from the National Kidney Foundation 2009 Spring Clinical Meetings

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

Practices face £50,000 pension cost hike under plan to raise employer contribution to 20.6%

Practices face £50,000 pension cost hike under plan to raise employer contribution to 20.6%

GP practices could face a five-figure hike in pension costs under plans to increase...

What medico-legal challenges will GPs face in 2019?

What medico-legal challenges will GPs face in 2019?

The MDU's head of advisory services, Dr Caroline Fryar, predicts which medico-legal...

GP practices providing online consultations doubled in 12 months, survey suggests

GP practices providing online consultations doubled in 12 months, survey suggests

The proportion of GP practices in England providing online consultations has almost...

Dr Nikita Kanani: Why peer support is the key to building a stronger general practice

Dr Nikita Kanani: Why peer support is the key to building a stronger general practice

NHS England's acting director of primary care Dr Nikita Kanani says connecting with...

Next-day GP appointments three times as likely to be missed as same-day bookings

Next-day GP appointments three times as likely to be missed as same-day bookings

Patients are nearly three times as likely to miss appointments booked with GP practices...

Outsourcing GP services overseas could be 'legal minefield', experts warn

Outsourcing GP services overseas could be 'legal minefield', experts warn

Using digital technology to outsource GP consultations overseas could leave the NHS...