Finnish researchers followed 231 children for two years. Febrile episodes were treated with rectal diclofenac or placebo, followed eight hours later by oral ibuprofen, paracetamol or placebo. The children experienced 89 febrile seizures over the course of the study.
There were no differences between the different treatment groups in terms of febrile seizure recurrence rates.
'Antipyretic agents were ineffective in the prevention of recurrent febrile seizures and in lowering the raised temperature during a febrile episode that led to a recurrent febrile seizure,' the researchers concluded.
The results suggest that use of antipyretic agents should not differ between patients with and without previous seizures, the researchers said.
'Parents should be informed about the inefficacy of antipyretic agents during a febrile episode that leads to a seizure and about the benign nature of febrile seizures.'