Dronedarone for AF rejected in draft NICE guidance

Dronedarone is not cost effective for AF treatment and cannot be recommended for use in the NHS, draft NICE guidance has concluded.

NICE research found that dronedarone cost more and was less effective

NICE said in a statement that the evidence it had reviewed in formulating the draft guidance suggested that dronedarone (Multaq) was less effective and cost ‘considerably more' than existing treatments for controlling AF.

NICE's chief executive Andrew Dillon said the institute was keen to help AF patients. ‘But,' he said, ‘we need to be sure that any treatment we recommend offers real additional benefits for patients — and we need to be confident that those benefits justify the cost to the NHS. In this case, dronedarone costs more, and has not been shown to be more effective, than other treatments for AF.'

Multaq's manufacturer Sanofi-aventis said it was disappointed at the decision.

'Multaq represents one of the most important pharmacological innovations in the treatment of AF for 20 years as it is the only anti-arrhythmic drug which, beyond prolonging time to AF recurrence and providing rate control, is proven to reduce the composite end-point of CV hospitalisation and death in AF patients, all achieved with a favourable safety profile,' the company said in a statement. 'No currently available anti-arrhythmic drugs have ever proven a clinical benefit in reducing outcomes in AF. Multaq represents a significant therapeutic advance in this regard.'

Sanofi-aventis said it would continue to work to ensure that Multaq is made available to those patients who will benefit from this new AF treatment.

NICE's draft recommendations is open to consultation until 28 January.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in


Just published

GP consultation

GP practices delivering 150,000 extra appointments per day compared with 2019

GP practices in England delivered 150,000 more appointments per working day in the...

Surgeon looking at a monitor in an operating theatre

NICE recommends non-invasive surgical procedure to target obesity

NICE has said that a non-invasive weight loss procedure should be used by the NHS...

GP trainee

Two training posts deliver one full-time GP on average, report warns

Two training posts are needed on average to deliver a single fully-qualified, full-time...

Dr Fiona Day

How to flourish as a GP by learning from the good and the difficult

Leadership and career coach Dr Fiona Day explains how GPs can grow and develop from...

Unhappy older woman sitting at home alone

Low mood – red flag symptoms

Low mood is a common presentation in primary care and can be a sign of a mental health...

Handshake

PCN to take on GMS practice contract in landmark move for general practice

A GP practice in Hertfordshire could become the first to be run directly by a PCN...