Doubts over use of rosuvastatin in HF

A statin fails to prevent cardiovascular death in elderly patients with heart failure, say Swedish scientists.

In a trial presented at the American Heart Association scientific sessions in Orlando, Florida, researchers said they failed to find an improvement in cardiovascular death rates among patients over 60 with systolic or ischaemic heart failure when given rosuvastatin.

In the study, 5,011 patients with moderate to severe heart failure were assigned rosuvastatin 10mg or placebo.

A reduction in cardiovascular events of 16 per cent was expected, said lead researcher Professor Ake Hjalmarson from the Sahlgrenska University Hospital in Goteborg.

A mean follow-up of two years and nine months found the rate of cardiovascular events was lowered by just 8 per cent.

But the number of hospitalisations for cardiovascular events in those given rosuvastatin was lower than in the placebo group.

It may be that rosuvastatin reduces acute atherothrombotic events in elderly heart failure patients, but has no effect on death rates in this group because this is primarily triggered by an electrical event related to ventricular dilatation and scarring, said Professor Hjalmarson.

Elisabeth Bjork, Astra Zeneca's global medical science director for rosuvastatin, said: 'The study included patients with advanced heart failure on optimal treatment who were not candidates for statin therapy.'

rachel.liddle@haymarket.com

AHA scientific sessions 4-7 November 2007, Orlando, Florida

Comment below and tell us what you think

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

GPs place first orders from government flu jab reserve as £12m support fund rolled out

GPs place first orders from government flu jab reserve as £12m support fund rolled out

GP practices can start ordering flu vaccine from an 8m-dose government stockpile...

Quarter of government's 8m-dose flu stockpile is vaccine granted temporary approval

Quarter of government's 8m-dose flu stockpile is vaccine granted temporary approval

A vaccine yet to be licensed in the UK accounts for more than a quarter of the 8m...

GPs report drop in older patients coming forward with cancer symptoms

GPs report drop in older patients coming forward with cancer symptoms

More than half of GPs say numbers of older patients coming forward with cancer symptoms...

Failure to involve GPs in COVID-19 test and trace 'a disaster and a national shame'

Failure to involve GPs in COVID-19 test and trace 'a disaster and a national shame'

GPs and primary care teams should have played a key role in the UK’s efforts to test,...

RCGP chair 'livid' over attacks on general practice from 'armchair critics'

RCGP chair 'livid' over attacks on general practice from 'armchair critics'

General practice has risen 'heroically' to unprecedented challenges during the COVID-19...

Remote GP consultations a 'lifeline for the NHS' during pandemic, says Hancock

Remote GP consultations a 'lifeline for the NHS' during pandemic, says Hancock

The rapid switch to remote GP consultations during the COVID-19 pandemic provided...