Doubt over use of rosuvastatin in heart failure

A statin fails to prevent cardiovascular death in elderly patients with heart failure (HF), say Swedish scientists.

In a trial presented at the American Heart Association (AHA) scientific sessions in Orlando, Florida, researchers said they failed to find an improvement in cardiovascular death rates among patients over 60 with systolic or ischaemic HF when given the statin rosuvastatin.

In the study of 5,011 patients with moderate to severe HF, patients were assigned rosuvastatin 10 mg or placebo.

A reduction in cardiovascular events of 16 per cent was expected, said lead researcher Professor Åke Hjalmarson from the Sahlgrenska University Hospital in Göteborg.

But after a mean follow-up of two years and nine months, researchers found that the rate of cardiovascular events was lowered by a non-significant 8 per cent in the treatment arm.

However, the number of hospitalisations for CV events in those given rosuvastatin was lower than in the placebo group.

Elisabeth Bjork, AstraZeneca’s global medical science director for rosuvastatin (Crestor), said: ‘The study included patients with advanced heart failure on optimal treatment who were not candidates for statin therapy.’

rachel.liddle@haymarket.com

More details on the Scientific Sessions 2007 website

Comment below and tell us what you think 

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

UK COVID-19 vaccination programme tracker

UK COVID-19 vaccination programme tracker

GPs across the UK are playing a leading role in the largest-ever NHS vaccination...

RCGP online exhibition celebrates women in general practice

RCGP online exhibition celebrates women in general practice

An online exhibition celebrating women’s contribution to general practice over the...

MPs back campaign against reforms that 'threaten fairness of fitness to practise cases'

MPs back campaign against reforms that 'threaten fairness of fitness to practise cases'

Plans to scrap the 'five-year rule' and categorise doctors with health concerns as...

GP appointments up 31% compared with pre-pandemic levels

GP appointments up 31% compared with pre-pandemic levels

General practice in England delivered 31% more appointments in June this year than...

COVID-19 vaccine map: Which CCGs have most fully-vaccinated adults?

COVID-19 vaccine map: Which CCGs have most fully-vaccinated adults?

Tens of millions of COVID-19 jabs have been administered across England, but progress...

RCGP demands emergency rescue package for 'crisis-torn' general practice

RCGP demands emergency rescue package for 'crisis-torn' general practice

A five-point rescue plan for general practice drawn up by the RCGP warns the profession...