Doubt over use of rosuvastatin in heart failure

A statin fails to prevent cardiovascular death in elderly patients with heart failure (HF), say Swedish scientists.

In a trial presented at the American Heart Association (AHA) scientific sessions in Orlando, Florida, researchers said they failed to find an improvement in cardiovascular death rates among patients over 60 with systolic or ischaemic HF when given the statin rosuvastatin.

In the study of 5,011 patients with moderate to severe HF, patients were assigned rosuvastatin 10 mg or placebo.

A reduction in cardiovascular events of 16 per cent was expected, said lead researcher Professor Åke Hjalmarson from the Sahlgrenska University Hospital in Göteborg.

But after a mean follow-up of two years and nine months, researchers found that the rate of cardiovascular events was lowered by a non-significant 8 per cent in the treatment arm.

However, the number of hospitalisations for CV events in those given rosuvastatin was lower than in the placebo group.

Elisabeth Bjork, AstraZeneca’s global medical science director for rosuvastatin (Crestor), said: ‘The study included patients with advanced heart failure on optimal treatment who were not candidates for statin therapy.’

rachel.liddle@haymarket.com

More details on the Scientific Sessions 2007 website

Comment below and tell us what you think 

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

UK hits 1m second doses of COVID-19 vaccine as campaign shifts to next phase

UK hits 1m second doses of COVID-19 vaccine as campaign shifts to next phase

More than 1m people UK-wide have now had two doses of COVID-19 vaccine, official...

UK COVID-19 vaccination programme tracker

UK COVID-19 vaccination programme tracker

GPs across the UK are playing a leading role in the largest-ever NHS vaccination...

What GPs need to know about the GMC's new guidance on prescribing

What GPs need to know about the GMC's new guidance on prescribing

MDU medico-legal adviser Kathryn Leask explains the key issues GPs need to be aware...

PCNs promised missing COVID-19 vaccine pay this month after cashflow warning

PCNs promised missing COVID-19 vaccine pay this month after cashflow warning

NHS England has promised to deliver thousands of pounds in missing payments to GP...

Chancellor's 'unfair tax on doctors' could drive 72% into early retirement, BMA warns

Chancellor's 'unfair tax on doctors' could drive 72% into early retirement, BMA warns

A five-year freeze on the pensions lifetime allowance in the government's 2021 budget...

Doctors warn of 'massive impact' on workforce as Sunak freezes pension lifetime allowance

Doctors warn of 'massive impact' on workforce as Sunak freezes pension lifetime allowance

Chancellor Rishi Sunak has confirmed a five-year freeze on the pension lifetime allowance...