A total of 231 laptops have gone missing since 2001/2, and 332 mobile phones.
In the last three years alone, DoH staff lost 151 mobile phones. Laptop losses peaked in 2008/9, with 34 lost in a single year.
The figures were released in a written answer from health minister Simon Burns (Con, Chelmsford) to a question from fellow MP Chris Skidmore (Con, Kingswood).
The written answer gives data on mobiles and laptops lost between 1997/8 and 2010/11. The total number of laptops lost in that period was 326, and the total number of mobile phones 446.
A DoH spokesman said the current average replacement value of a laptop was around £850. Based on this figure, the 231 laptops lost in the last 10 years would cost £196,350 to replace.
Blackberry mobile phones cost around £215 each to replace, the DoH spokesman said, but many of the phones lost were likely to be lower-value models.