DoH staff lost 14 of the 53 laptops or PCs reported missing by the government, followed by the Department for Children, Schools and Families, which lost 13.
The Ministry of Defence and the Home Office declined to provide figures.
A DoH statement said that it only recorded one data breach during the year. This involved the Medical Training Application Service website where personal details of some junior doctors were erroneously made available.
Government departments have lost an average of one official computer a week over the past year.
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