Talking at a fringe event at the Conservative Party Conference in Birmingham on Monday, Dr Richard Vautrey said the government's drive to make PCTs 'fill out forms' and 'tick boxes' had to stop.
He said one of the biggest threats to the White Paper reforms was if the government did not allow commissioning to 'work properly' by putting unreasonable demands on commissioners.
Dr Vautrey said: 'The only reason PCTs are the size they are and have the bureaucracy they have is because the DoH historically has asked so much of PCTs, with various boxes to tick, forms to fill out and reports to write.
'This has to stop. Because if it doesn't then these new embryonic GP-led consortia will not be able to deliver. There has to be a rationalisation here and it has to start with the DoH.'
Dr Vautrey also called for the government to give the reforms time to embed. He said this is a major failing of previous reorganisations.
He said: 'We have got to give these reforms a chance to work. If we do, they can work and will work well.'