The facilities are the first to be paid for from a £750 million fund for new community hospitals and services to provide NHS patients with minor operations, medical tests and follow-up care outside of larger hospitals.
The services will be in Sunderland, Bristol, Gosport in Hampshire and Minehead in Somerset.
They will offer speedy access to medical checks, ranging from hearing tests to endoscopies, as well as day surgery and urgent care units.
It is expected that the new units will perform around 25,000 medical tests, treat 30,000 minor injuries and handle 20,000 outpatient appointments each year in a major shift of care into community settings.
Earlier this year the DoH invited PCTs to bid for capital funding to build a network of community hospitals, health centres and polyclinics.
These first four successful bids represent just those PCTs with the most advanced plans. A further round of proposals is expected from PCTs in January.
