DNA affects how patients respond to COPD therapy

Small variations in the sequences of certain genes may explain why COPD patients respond differently to inhaled bronchodilators, researchers have said.

Subtle differences in genetic makeup may affect COPD treatment response (Photo: Jim Varney)
Subtle differences in genetic makeup may affect COPD treatment response (Photo: Jim Varney)

A meta-analysis from an international team of researchers suggests genetic differences in four genes may account for variable FEV1 response to salbutamol.

The study, presented at the American Society of Human Genetics 2013 meeting in Boston this week, examined the DNA of 5,789 white and more than 700 African-American patients with moderate to severe COPD. Most had a smoking history of more than 10 pack-years.

All patients' DNA was analysed for the presence of single nucleotide polymorphisms (SNPs) and spirometry used to measure airflow to the lungs.

To assess each patient's response to salbutamol, the absolute change in FEV1, change as a percentage of predicted FEV1 and change as a percentage of baseline FEV1 were measured.

Researchers linked SNPs in the gene HS6ST3 to differences in baseline FEV1 measures, while patients with SNPs in XKR4 were more likely to see differences in baseline and predicted FEV1 response.

Similarly, SNPs in CUBN were associated with differences in absolute and predicted FEV1 response, while in African-American patients, SNPs in CDH13 were linked to absolute FEV1 measures.

Study author Megan Hardin, of Harvard Medical School, Boston, said: 'Identifying SNPs associated with bronchodilator responsiveness may reveal genetic pathways associated with the pathogenesis of COPD and may identify novel treatment methods.'

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

£20 notes spread out

VAT trap for PCNs could strip millions of pounds from general practice

Tens of millions of pounds could be stripped from general practice because work carried...

Talking General Practice logo

Podcast: Is the BMA representing GPs effectively, why GPs face a pension tax hit, and views on the workload crisis

In our regular news review the team discusses representation of GPs, a new survey...

Man sleeping

NICE guidance on insomnia backs app to replace sleeping pills

Hundreds of thousands of people with insomnia could be offered treatment via a mobile...

Health worker prepares a dose of COVID-19 vaccine

JCVI backs autumn COVID-19 booster campaign for high-risk adults and NHS staff

Frontline health and social care staff and adults at increased risk of severe illness...

GP consultation

Government accused of 'misleading' claims on general practice workforce

GP leaders have accused the government of making misleading claims about the general...

Consulting room door

LMC calls for enhanced access to be scrapped after abuse forces practice to close reception

A Midlands LMC has backed a practice forced to close its reception desk after abuse...