Clozapine doubles metabolic risk

Patients taking the antipsychotic clozapine are twice as likely to have the metabolic syndrome, US researchers have warned.

They measured levels of cardiometabolic risk factors in 93 patients taking clozapine and compared them with a reference group of 2,700 Americans matched for age, BMI and race.

Over 53 per cent of the patients taking clozapine were found to have the metabolic syndrome, compared to 20.7 per cent of the reference group.

The researchers recommended close monitoring for diabetes and cardiovascular disease.

- Am J Psychiatry online.

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