Breast cancer gene linked to lung cancer deaths

A gene that increases susceptibility to breast cancer may also predict worse outcomes in lung cancer patients, a European study has shown.

High levels of the BRCA1 breast cancer gene have been shown to double the risk of mortality over three years following surgery for non-small cell lung cancer (NSCLC).

Outcomes in NSCLC patients could be improved by offering adjuvant chemotherapy to those with high levels of the gene, the researchers suggested.

They analysed tumour samples taken from 126 Polish patients during surgery for NSCLC.

They then measured levels of five genes believed to play a role in progression of NSCLC, including BRCA1.

Of the five genes, only BRCA1 was found to be predictive of survival. Patients with high levels of BRCA1 expression had a 98 per cent increased risk of dying within three years of surgery, compared with patients with low levels of BRCA1.

Event free survival in the 36 patients whose tumours had high levels of BRCA1 was 22 months on average.

Additional study of NSCLC tumour samples from a separate group of 58 patients, confirmed that high BRCA1 expression more than doubled the risk of death.

gpletters@haynet.com

European J Cancer Supp. 2007; 5 (4); 358
www.ecco-org.eu

Comment below and tell us what you think

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

Under 40s to be offered alternative to AstraZeneca COVID-19 vaccine

Under 40s to be offered alternative to AstraZeneca COVID-19 vaccine

Patients aged 30-39 will be offered an alternative to the Oxford/AstraZeneca COVID-19...

GPs per patient down 10% in just five years, NHS data reveal

GPs per patient down 10% in just five years, NHS data reveal

The number of fully-qualified, full-time equivalent (FTE) GPs per patient in England...

Supportive model must replace harmful CQC inspections, BMA chair warns

Supportive model must replace harmful CQC inspections, BMA chair warns

CQC inspections that ‘divert time away from patient care’ and ‘instil fear’ among...

UK COVID-19 vaccination programme tracker

UK COVID-19 vaccination programme tracker

GPs across the UK are playing a leading role in the largest-ever NHS vaccination...

A 'tsunami' of work is drowning general practice: GPs speak out about a profession at its limit

A 'tsunami' of work is drowning general practice: GPs speak out about a profession at its limit

Rocketing workloads created by huge backlogs of cases and continuing COVID-19 disruption...

Slight increase in GP workforce during past year, but number of partners continues to fall

Slight increase in GP workforce during past year, but number of partners continues to fall

The GP workforce grew by 0.4% in the year to March 2021, but the number of GP partners...