Researchers from Hull Royal Infirmary found that variation in BP is a risk factor in the development of nephropathy and its effects are independent of mean BP.
The team studied data from the Diabetes Control and Complications Trial (DCCT) involving 1,441 patients with type-1 diabetes.
The DCCT compared the effect of intensive versus conventional blood glucose control on the development of microvascular complications of diabetes.
Researchers studied 1,261 patients and looked at the variability of BP readings between consultations. Primary outcomes were defined as instances of retinopathy and nephropathy.
They found that while mean diastolic BP was linked to the development of retinopathy, BP variability was not as important.
However, researchers believe BP variability contributed to the appearance of nephropathy among patients.
They concluded: ‘In contrast to retinopathy, visit-to-visit variability in BP consistently added to mean BP in predicting the risk of developing albuminuria among the patients participating in the DCCT.’
‘This observation could have implications for the management and treatment of BP in patients with type-1 diabetes.’