Involving 8,351 patients with or at risk from atherosclerosis undergoing surgery, participants were randomly assigned to receive the beta-blocker metoprolol succinate or placebo.
Treatment was started two to four hours prior to surgery and continued for 30 days.
Analysis showed that for every 1,000 patients treated with a beta-blocker, there would be 8 excess deaths, 5 patients who suffer stroke, 53 with clinically significant hypotension and 42 with clinical significant bradycardia.
However, the treatment would also prevent 15 MIs, 3 cardiac revascularisations and 7 new cases of AF.
Comment below and tell us what you think