'Avoid NSAIDs with SSRIs'

Patients taking SSRIs should be warned against taking concomitant NSAIDs, say UK researchers.

SSRIs alone can double a person's risk of upper GI bleeding, but the risk rises to six-fold if NSAIDs are also taken.

The findings come from a meta-analysis of four studies involving 153,000 patients.

GPs should take a detailed GI history from patients before prescribing SSRIs and try to only give them to those at low risk of upper GI bleeding, say the researchers.

Patients taking SSRIs and NSAIDs should be told to stop taking the painkillers as soon as possible, consider treatment with proton pump inhibitors or switch to a different type of painkiller, the researchers added.

Dr Richard Stevens, Oxford GP and chairman of the Primary Care Society for Gastroenterology, said: 'If you can get away without prescribing SSRIs or NSAIDs, perfect. If you're going to do this, co-prescribe some gastroprotection. But also warn the patient to report any bleeding.'

Comment below and tell us what you think

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:


Just published

Mobile phone

GPs urge caution over plan for NHS health checks to go digital

GP leaders have warned that changes to the NHS health checks programme must be evidence-based...

Debbie Boughtflower

How career coaching can transform the lives of veterans

GPs across England and Wales can refer patients who used to work in the armed forces...

RCGP chair Professor Kamila Hawthorne

RCGP raises 'major concerns' over practice-level appointments data

The RCGP has written to health and social care secretary Steve Barclay warning that...

Labour shadow health and social care secretary Wes Streeting

GPs condemn 'ignorant' Labour rhetoric over access to appointments

Doctors' leaders have accused the Labour party of 'demonising' GPs after it claimed...

coins

Government NHS pension reform plans 'too little too late', warns BMA

Government plans to boost retention of doctors through reforms to the NHS pension...

Child in bed with a fever

GPs told to have 'low threshold' for prescribing antibiotics in possible strep A cases

GPs have been urged to have a 'low threshold' for prescribing antibiotics and hospital...