Asthma drug 'linked to adverse events'

The asthma drug formoterol increases patients' risk of non-fatal serious adverse events, a Cochrane review suggests.

The review of 22 studies involving 8,032 patients looked at the risk of fatal and non-fatal serious adverse events for patients taking formoterol, compared with those given placebo or the short-acting beta-2 agonist salbutamol.

Formoterol is a long-acting beta-2 agonist, a class of medicines whose safety has been called into question previously.

Too few deaths occurred in the studies to assess any differences in the risk of fatal serious adverse events.

Non-fatal serious adverse events, however, were increased by 57 per cent in patients given formoterol compared with those on placebo. No significant increase in either fatal or non-fatal events was seen with salbutamol.

AstraZeneca, which manufactures Oxis and the combination product Symbicort, which contain formoterol, told GP that a recent review of 80,000 patients showed that formoterol-containing products reduced risk of serious adverse events.

The company believes this reflects real-life practice more accurately than the clinical trial data used in the Cochrane review.

It said it has sent the data to the Cochrane Collaboration.

Novartis, manufacturer of Foradil, which also contains formoterol, said that data from 10 million patient-years of exposure showed a positive benefit/risk ratio for formoterol. A spokesman said people should not stop taking medications unless advised to by a doctor.

Cochrane Library

Comment below and tell us what you think

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins


Already registered?

Sign in

Follow Us:

Just published

£20 notes spread out

VAT trap for PCNs could strip millions of pounds from general practice

Tens of millions of pounds could be stripped from general practice because work carried...

Talking General Practice logo

Podcast: Is the BMA representing GPs effectively, why GPs face a pension tax hit, and views on the workload crisis

In our regular news review the team discusses representation of GPs, a new survey...

Man sleeping

NICE guidance on insomnia backs app to replace sleeping pills

Hundreds of thousands of people with insomnia could be offered treatment via a mobile...

Health worker prepares a dose of COVID-19 vaccine

JCVI backs autumn COVID-19 booster campaign for high-risk adults and NHS staff

Frontline health and social care staff and adults at increased risk of severe illness...

GP consultation

Government accused of 'misleading' claims on general practice workforce

GP leaders have accused the government of making misleading claims about the general...

Consulting room door

LMC calls for enhanced access to be scrapped after abuse forces practice to close reception

A Midlands LMC has backed a practice forced to close its reception desk after abuse...