Aspirin 'fails to cut vascular events'

Even among high-risk groups, aspirin does not reduce patients' risk of suffering a vascular event, UK research suggests.

Stroke: 'lack of statistical power' might have masked small effects (Photograph: SPL)
Stroke: 'lack of statistical power' might have masked small effects (Photograph: SPL)

Dr Gerald Fowkes and colleagues from the University of Edinburgh used ankle brachial index (ABI) as a marker of vascular event risk. They studied the effectiveness of aspirin at preventing vascular events in a group of 3,350 healthy people with a low ABI.

Half took aspirin 100mg once daily, while the other half were given a placebo.

After more than eight years, the researchers found there was no difference in the vascular event rate between the two groups, suggesting aspirin offers no protection against vascular events in those at high risk.

There were 13.7 events per 1,000 person-years in the aspirin group, compared with 13.3 events in the placebo group.

The researchers said a lack of statistical power to detect small effects of aspirin may have affected the study's outcome.

The trial was designed to be able to detect a 25 per cent risk reduction in vascular events among participants. But the researchers suggest that this estimate may have been too high.

The study findings suggested a possible risk reduction of around 16 per cent, the researchers said.

But a risk reduction of this size would be outweighed by the increased risk of major haemorrhage and GI ulcer, as well as more instances of fatal intracranial adverse events in the aspirin group, the researchers said.

Writing in an accompanying editorial, Dr Jeffrey Berger of the New York University School of Medicine said the trial may have implications for screening using ABI.

'Because aspirin did not reduce rates of cardiovascular events in the participants found to have low ABI, these data do not support recommendations for ABI screening in an effort to ultimately reduce cardiovascular disease event rates in patients at risk for peripheral artery disease,' he wrote.

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register

Already registered?

Sign in

Follow Us:

Just published

A day in the life of a prison GP

A day in the life of a prison GP

Dr Patrick Staite tells GP Jobs what it is like to work as a prison GP.

GP practice list size up nearly 50% since 2004 contract

GP practice list size up nearly 50% since 2004 contract

The average GP practice list in England has increased by almost half since the new...

Fresh calls to scrap Capita contract as more cervical screening failures emerge

Fresh calls to scrap Capita contract as more cervical screening failures emerge

The BMA has renewed calls for NHS England to strip Capita of its primary care support...

Cost-effectiveness of GP at Hand 'challenging' to assess, interim report warns

Cost-effectiveness of GP at Hand 'challenging' to assess, interim report warns

The cost-effectiveness of the Babylon GP at Hand service will be difficult to determine...

How we improved end-of-life care in our practice

How we improved end-of-life care in our practice

Dr Victoria Middleton explains how her practice has increased the number of patients...

12,000-patient practice forced to close after service charge hike

12,000-patient practice forced to close after service charge hike

A 12,000-patient GP practice in Nottinghamshire has been forced to hand back its...